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              Research
              
                            
              
                            
              4.   
                  
                  
                              
                              Cod liver oil/honey mixture: An effective 
                              treatment of equine complicated lower leg wounds - Magda Mahmoud Ali, Khaled Radad
                              Vet World. 2011; 4(7): 304-310
               
              
              
              doi: 10.5455/vetworld.2011.304-310
              
              
               
              
              
              
   
 
              
               
               
               
              
              
              Abstract
              
                              
                              
                              Wounds are of great concern in animals as they 
                              affect animal productivity and their treatment 
                              represents an economic burden to the owners 
                              particularly in developing countries. The present 
                              study investigated the beneficial role of a 
                              mixture of cod liver oil and honey in treatment of 
                              old wounds in equines. In which, 3 horses and 7 
                              donkeys were admitted to the Veterinary Teaching 
                              Hospital at Assiut University, Assiut, Egypt with 
                              old wounds at the metacarpus (5 cases) and 
                              metatarsus (3 cases) and at the level of fetlock 
                              and carpal joints (one case each). Treatment of 
                              these wounds with cod liver oil/honey mixture 
                              markedly decreased their sizes and resulted in 
                              formation of a healthy scar after one month of 
                              treatment. To explain the mechanisms that underlie 
                              the effects of this mixture, 9 surgically-induced 
                              wounds at the metacarpus in 9 donkeys were treated 
                              with honey, cod liver oil or the mixture (3 wounds 
                              each) and compared with parallel untreated control 
                              wounds at the metatarsus. It was found that 
                              treatment of wounds with honey, cod liver oil and 
                              the mixture apparently decreased the size of 
                              wounds. Histopathological examination revealed 
                              that treated wounds with honey or cod liver oil 
                              showed complete epithelization over the wound 
                              areas. On the other hand, epithelization process 
                              was not complete in wounds treated with the 
                              mixture. Granulation tissue showed some 
                              variability between different treatments. Of 
                              which, wounds treated with the mixture showed a 
                              higher degree of maturity with increasing numbers 
                              of fibrocytes and parallel collagenous fibers. 
                              This could underlie the good results obtained in 
                              case studied wounds with the mixture. In 
                              conclusion, mixture of cod liver oil and honey is 
                              beneficial in treatment of old traumatized wounds 
                              in equine and this effect is primarily mediated by 
                              formation of healthy and mature scars. Cod liver 
                              oil or honey alone is beneficial for healing of 
                              recent and surgical wounds as they facilitate 
                              epithelization process. 
              
                              
              Keywords: Equine, 
                              Wound, Healing, Honey, Cod liver oil.